251772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3639675..3640258 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag NML17_RS17790 Protein ID WP_000254745.1
Coordinates 3639675..3640010 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag NML17_RS17795 Protein ID WP_000581937.1
Coordinates 3640010..3640258 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS17770 (3635144) 3635144..3635506 + 363 WP_000034929.1 hypothetical protein -
NML17_RS17775 (3635562) 3635562..3636860 - 1299 WP_000036723.1 phosphopyruvate hydratase -
NML17_RS17780 (3636948) 3636948..3638585 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
NML17_RS17785 (3638813) 3638813..3639604 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
NML17_RS17790 (3639675) 3639675..3640010 - 336 WP_000254745.1 endoribonuclease MazF Toxin
NML17_RS17795 (3640010) 3640010..3640258 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NML17_RS17800 (3640336) 3640336..3642570 - 2235 WP_000226815.1 GTP pyrophosphokinase -
NML17_RS17805 (3642618) 3642618..3643919 - 1302 WP_000046790.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T251772 WP_000254745.1 NZ_CP101274:c3640010-3639675 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT251772 WP_000581937.1 NZ_CP101274:c3640258-3640010 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References