251771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3348732..3349357 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NML17_RS16355 Protein ID WP_000911330.1
Coordinates 3348732..3349130 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NML17_RS16360 Protein ID WP_000450524.1
Coordinates 3349130..3349357 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS16335 (3344610) 3344610..3344810 + 201 WP_000383836.1 YpfN family protein -
NML17_RS16340 (3344920) 3344920..3345618 - 699 WP_000679823.1 esterase -
NML17_RS16345 (3345692) 3345692..3347707 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
NML17_RS16350 (3347722) 3347722..3348585 - 864 WP_001267508.1 neutral zinc metallopeptidase -
NML17_RS16355 (3348732) 3348732..3349130 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NML17_RS16360 (3349130) 3349130..3349357 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NML17_RS16365 (3349511) 3349511..3350224 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NML17_RS16370 (3350437) 3350437..3351471 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NML17_RS16375 (3351488) 3351488..3352366 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NML17_RS16380 (3352512) 3352512..3353084 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NML17_RS16385 (3353084) 3353084..3353554 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T251771 WP_000911330.1 NZ_CP101274:c3349130-3348732 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251771 WP_000450524.1 NZ_CP101274:c3349357-3349130 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References