Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2486481..2487123 Replicon chromosome
Accession NC_015376
Organism Burkholderia gladioli BSR3

Toxin (Protein)


Gene name vapC Uniprot ID F2LQ48
Locus tag BGLA_RS29320 Protein ID WP_013690721.1
Coordinates 2486481..2486903 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F2LQ49
Locus tag BGLA_RS29325 Protein ID WP_013690722.1
Coordinates 2486890..2487123 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGLA_RS29300 2482281..2483654 + 1374 WP_013690717.1 L-fucose:H+ symporter permease -
BGLA_RS29305 2483657..2484739 + 1083 WP_013690718.1 aldose 1-epimerase family protein -
BGLA_RS29310 2484759..2485529 - 771 WP_013690719.1 DNA-binding transcriptional repressor DeoR -
BGLA_RS29315 2485679..2486359 + 681 WP_013690720.1 deoxyribose-phosphate aldolase -
BGLA_RS29320 2486481..2486903 - 423 WP_013690721.1 type II toxin-antitoxin system VapC family toxin Toxin
BGLA_RS29325 2486890..2487123 - 234 WP_013690722.1 DNA-binding protein Antitoxin
BGLA_RS29330 2487439..2488428 - 990 WP_013690723.1 LysR family transcriptional regulator -
BGLA_RS42065 2488622..2488885 - 264 WP_148270457.1 hypothetical protein -
BGLA_RS29335 2489017..2490783 + 1767 WP_013690724.1 AMP-binding protein -
BGLA_RS29340 2490908..2491156 + 249 WP_013690725.1 acyl carrier protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15649.91 Da        Isoelectric Point: 8.5438

>T25177 WP_013690721.1 NC_015376:c2486903-2486481 [Burkholderia gladioli BSR3]
MYLIDTNVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDESQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

>T25177 NC_015376:c2486903-2486481 [Burkholderia gladioli BSR3]
ATGTATTTGATTGACACCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGTGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACGAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCTCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGATGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8570.70 Da        Isoelectric Point: 5.0618

>AT25177 WP_013690722.1 NC_015376:c2487123-2486890 [Burkholderia gladioli BSR3]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHREILARALREPQRKTFAQVLMGMPNVGSDADFARVDDGEAVNVFD

Download         Length: 234 bp

>AT25177 NC_015376:c2487123-2486890 [Burkholderia gladioli BSR3]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGAAATCCTGGCAAGGGCGCTGCGCGAGCCGCAGCGCAAGACATTCGCGCAAGTGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGTGAATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A833Q1H0

Antitoxin

Source ID Structure
AlphaFold DB F2LQ49

References