Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1084342..1084960 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML17_RS05180 Protein ID WP_001291435.1
Coordinates 1084342..1084560 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML17_RS05185 Protein ID WP_000344800.1
Coordinates 1084586..1084960 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS05145 (1079631) 1079631..1080203 + 573 WP_000779831.1 YbaY family lipoprotein -
NML17_RS05150 (1080234) 1080234..1080545 - 312 WP_000409911.1 MGMT family protein -
NML17_RS05160 (1080924) 1080924..1081277 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NML17_RS05165 (1081319) 1081319..1082869 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML17_RS05170 (1083033) 1083033..1083503 - 471 WP_000136192.1 YlaC family protein -
NML17_RS05175 (1083619) 1083619..1084170 - 552 WP_000102568.1 maltose O-acetyltransferase -
NML17_RS05180 (1084342) 1084342..1084560 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NML17_RS05185 (1084586) 1084586..1084960 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML17_RS05190 (1085506) 1085506..1088655 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML17_RS05195 (1088678) 1088678..1089871 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251760 WP_001291435.1 NZ_CP101274:c1084560-1084342 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251760 WP_000344800.1 NZ_CP101274:c1084960-1084586 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References