251756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 384578..385173 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NML17_RS01810 Protein ID WP_000239579.1
Coordinates 384823..385173 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NML17_RS01805 Protein ID WP_001223208.1
Coordinates 384578..384829 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS01795 (380242) 380242..384021 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
NML17_RS01800 (384024) 384024..384365 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NML17_RS01805 (384578) 384578..384829 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NML17_RS01810 (384823) 384823..385173 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NML17_RS01815 (385253) 385253..385783 - 531 WP_000055072.1 inorganic diphosphatase -
NML17_RS01820 (386093) 386093..387049 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NML17_RS01825 (387359) 387359..388861 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NML17_RS01830 (388872) 388872..389897 + 1026 WP_254815514.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T251756 WP_000239579.1 NZ_CP101274:384823-385173 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT251756 WP_001223208.1 NZ_CP101274:384578-384829 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References