Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 63557..64182 Replicon plasmid pEC21Z048-116K
Accession NZ_CP101270
Organism Escherichia coli strain EC21Z-048

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NML18_RS23720 Protein ID WP_000911324.1
Coordinates 63784..64182 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag NML18_RS23715 Protein ID WP_000450532.1
Coordinates 63557..63784 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML18_RS23715 (63557) 63557..63784 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
NML18_RS23720 (63784) 63784..64182 + 399 WP_000911324.1 type II toxin-antitoxin system VapC family toxin Toxin
NML18_RS23725 (64191) 64191..66344 - 2154 WP_000009350.1 type IV conjugative transfer system coupling protein TraD -
NML18_RS23730 (66597) 66597..67307 - 711 WP_042032882.1 conjugal transfer complement resistance protein TraT -
NML18_RS23735 (67353) 67353..67874 - 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeI / faeH / faeF / faeE / faeD / faeC 1..115682 115682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.09 Da        Isoelectric Point: 7.8604

>T251750 WP_000911324.1 NZ_CP101270:63784-64182 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT251750 WP_000450532.1 NZ_CP101270:63557-63784 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References