Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4220801..4221396 Replicon chromosome
Accession NZ_CP101269
Organism Escherichia coli strain EC21Z-048

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NML18_RS20580 Protein ID WP_000239579.1
Coordinates 4220801..4221151 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NML18_RS20585 Protein ID WP_001223208.1
Coordinates 4221145..4221396 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML18_RS20560 (4216077) 4216077..4217099 - 1023 WP_001296689.1 ABC transporter permease -
NML18_RS20565 (4217113) 4217113..4218615 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
NML18_RS20570 (4218925) 4218925..4219881 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NML18_RS20575 (4220191) 4220191..4220721 + 531 WP_000055072.1 inorganic diphosphatase -
NML18_RS20580 (4220801) 4220801..4221151 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NML18_RS20585 (4221145) 4221145..4221396 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NML18_RS20590 (4221609) 4221609..4221950 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NML18_RS20595 (4221953) 4221953..4225732 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T251745 WP_000239579.1 NZ_CP101269:c4221151-4220801 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT251745 WP_001223208.1 NZ_CP101269:c4221396-4221145 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References