Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3530262..3530880 Replicon chromosome
Accession NZ_CP101269
Organism Escherichia coli strain EC21Z-048

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML18_RS17290 Protein ID WP_001291435.1
Coordinates 3530662..3530880 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML18_RS17285 Protein ID WP_000344800.1
Coordinates 3530262..3530636 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML18_RS17275 (3525351) 3525351..3526544 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML18_RS17280 (3526567) 3526567..3529716 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML18_RS17285 (3530262) 3530262..3530636 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML18_RS17290 (3530662) 3530662..3530880 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML18_RS17295 (3531052) 3531052..3531603 + 552 WP_000102564.1 maltose O-acetyltransferase -
NML18_RS17300 (3531719) 3531719..3532189 + 471 WP_000136192.1 YlaC family protein -
NML18_RS17305 (3532353) 3532353..3533903 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML18_RS17310 (3533945) 3533945..3534298 - 354 WP_000878141.1 DUF1428 family protein -
NML18_RS17320 (3534677) 3534677..3534988 + 312 WP_000409911.1 MGMT family protein -
NML18_RS17325 (3535019) 3535019..3535591 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251740 WP_001291435.1 NZ_CP101269:3530662-3530880 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251740 WP_000344800.1 NZ_CP101269:3530262-3530636 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References