Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 629070..629654 Replicon chromosome
Accession NC_015376
Organism Burkholderia gladioli BSR3

Toxin (Protein)


Gene name relE Uniprot ID F2LKS5
Locus tag BGLA_RS21890 Protein ID WP_013689303.1
Coordinates 629358..629654 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F2LKS4
Locus tag BGLA_RS21885 Protein ID WP_013689302.1
Coordinates 629070..629354 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGLA_RS21865 624150..625433 - 1284 WP_013689299.1 4-aminobutyrate--2-oxoglutarate transaminase -
BGLA_RS21870 625569..627224 + 1656 WP_013689300.1 PLP-dependent aminotransferase family protein -
BGLA_RS21875 627410..628537 + 1128 WP_165650560.1 ABC transporter substrate-binding protein -
BGLA_RS21880 628686..629012 + 327 WP_044274799.1 hypothetical protein -
BGLA_RS21885 629070..629354 - 285 WP_013689302.1 putative addiction module antidote protein Antitoxin
BGLA_RS21890 629358..629654 - 297 WP_013689303.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BGLA_RS21895 629778..630716 - 939 WP_013689304.1 ketopantoate reductase family protein -
BGLA_RS21900 630873..631343 + 471 WP_013689305.1 Lrp/AsnC family transcriptional regulator -
BGLA_RS21905 631387..632223 - 837 WP_013689306.1 DMT family transporter -
BGLA_RS21910 632454..633515 + 1062 WP_013689307.1 selenide, water dikinase SelD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(11-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11273.12 Da        Isoelectric Point: 10.4966

>T25174 WP_013689303.1 NC_015376:c629654-629358 [Burkholderia gladioli BSR3]
MVTLLRSSEFTNWLSSLRDQRGKARIAARLISAQLGNFGEYRVIGEGVREMKVDFGPGYRIYYVRRAEIVYVLLCGGDKS
TQKKDIKRALQMARELKE

Download         Length: 297 bp

>T25174 NC_015376:c629654-629358 [Burkholderia gladioli BSR3]
ATGGTAACTTTGCTGCGCTCCAGTGAATTCACAAACTGGCTTTCCAGCCTGCGTGATCAGCGCGGCAAAGCCCGAATCGC
CGCACGCCTGATCAGTGCCCAGCTAGGCAATTTTGGCGAGTACCGCGTGATAGGCGAAGGCGTCCGCGAAATGAAGGTCG
ACTTCGGGCCGGGTTATCGCATCTACTATGTCCGTCGCGCCGAGATCGTCTATGTCCTTCTCTGCGGTGGCGATAAATCT
ACACAGAAAAAAGACATCAAGCGCGCGCTCCAGATGGCGCGCGAACTGAAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10102.49 Da        Isoelectric Point: 5.0484

>AT25174 WP_013689302.1 NC_015376:c629354-629070 [Burkholderia gladioli BSR3]
MPDYAEFDAADYLDNDETVAEFLAVAAEDPDPAVFLAAVAAVARARGMTKVASEAGLGRVTLHKALTPGAHPRYETVQKI
LRSLGLRMTFTVTH

Download         Length: 285 bp

>AT25174 NC_015376:c629354-629070 [Burkholderia gladioli BSR3]
ATGCCCGATTACGCCGAATTCGATGCGGCCGACTATCTCGACAATGACGAAACCGTGGCGGAATTTCTCGCGGTTGCGGC
CGAGGATCCCGATCCCGCAGTGTTCCTTGCTGCCGTGGCCGCTGTCGCACGCGCGCGCGGGATGACCAAGGTGGCATCGG
AAGCCGGCCTTGGACGGGTCACCTTGCACAAGGCGCTGACGCCTGGCGCTCACCCTCGATATGAGACCGTGCAGAAGATC
CTGCGCTCGCTGGGCCTTCGCATGACCTTCACCGTCACCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A560UNN5

Antitoxin

Source ID Structure
AlphaFold DB F2LKS4

References