Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2508896..2509534 Replicon chromosome
Accession NZ_CP101269
Organism Escherichia coli strain EC21Z-048

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NML18_RS12290 Protein ID WP_000813794.1
Coordinates 2509358..2509534 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NML18_RS12285 Protein ID WP_001270286.1
Coordinates 2508896..2509312 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML18_RS12265 (2504048) 2504048..2504989 - 942 WP_001251315.1 ABC transporter permease -
NML18_RS12270 (2504990) 2504990..2506003 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
NML18_RS12275 (2506021) 2506021..2507166 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NML18_RS12280 (2507411) 2507411..2508817 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
NML18_RS12285 (2508896) 2508896..2509312 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NML18_RS12290 (2509358) 2509358..2509534 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NML18_RS12295 (2509756) 2509756..2509986 + 231 WP_000494244.1 YncJ family protein -
NML18_RS12300 (2510078) 2510078..2512039 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NML18_RS12305 (2512112) 2512112..2512648 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NML18_RS12310 (2512740) 2512740..2513915 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T251739 WP_000813794.1 NZ_CP101269:c2509534-2509358 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT251739 WP_001270286.1 NZ_CP101269:c2509312-2508896 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References