Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 608278..608896 | Replicon | chromosome |
| Accession | NC_015315 | ||
| Organism | Thermoproteus uzoniensis 768-20 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | F2L4L7 |
| Locus tag | TUZN_RS03375 | Protein ID | WP_013679531.1 |
| Coordinates | 608498..608896 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | F2L4L6 |
| Locus tag | TUZN_RS03370 | Protein ID | WP_013679530.1 |
| Coordinates | 608278..608514 (+) | Length | 79 a.a. |
Genomic Context
Location: 603662..604813 (1152 bp)
Type: Others
Protein ID: WP_013679525.1
Type: Others
Protein ID: WP_013679525.1
Location: 604917..605396 (480 bp)
Type: Others
Protein ID: WP_013679526.1
Type: Others
Protein ID: WP_013679526.1
Location: 608278..608514 (237 bp)
Type: Antitoxin
Protein ID: WP_013679530.1
Type: Antitoxin
Protein ID: WP_013679530.1
Location: 608498..608896 (399 bp)
Type: Toxin
Protein ID: WP_013679531.1
Type: Toxin
Protein ID: WP_013679531.1
Location: 612055..612555 (501 bp)
Type: Others
Protein ID: WP_013679534.1
Type: Others
Protein ID: WP_013679534.1
Location: 612585..613088 (504 bp)
Type: Others
Protein ID: WP_013679535.1
Type: Others
Protein ID: WP_013679535.1
Location: 613085..613573 (489 bp)
Type: Others
Protein ID: WP_013679536.1
Type: Others
Protein ID: WP_013679536.1
Location: 605632..606903 (1272 bp)
Type: Others
Protein ID: WP_013679527.1
Type: Others
Protein ID: WP_013679527.1
Location: 606916..607506 (591 bp)
Type: Others
Protein ID: WP_013679528.1
Type: Others
Protein ID: WP_013679528.1
Location: 607839..608015 (177 bp)
Type: Others
Protein ID: WP_013679529.1
Type: Others
Protein ID: WP_013679529.1
Location: 609144..610256 (1113 bp)
Type: Others
Protein ID: WP_013679532.1
Type: Others
Protein ID: WP_013679532.1
Location: 610249..611892 (1644 bp)
Type: Others
Protein ID: WP_013679533.1
Type: Others
Protein ID: WP_013679533.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TUZN_RS03345 (TUZN_0698) | 603662..604813 | + | 1152 | WP_013679525.1 | cobalamin-independent methionine synthase II family protein | - |
| TUZN_RS03350 (TUZN_0699) | 604917..605396 | + | 480 | WP_013679526.1 | PaREP1 family protein | - |
| TUZN_RS11425 (TUZN_0700) | 605632..606903 | - | 1272 | WP_013679527.1 | hypothetical protein | - |
| TUZN_RS03360 (TUZN_0701) | 606916..607506 | - | 591 | WP_013679528.1 | MarC family protein | - |
| TUZN_RS11430 (TUZN_0703) | 607839..608015 | - | 177 | WP_013679529.1 | chromatin protein Cren7 | - |
| TUZN_RS03370 (TUZN_0704) | 608278..608514 | + | 237 | WP_013679530.1 | hypothetical protein | Antitoxin |
| TUZN_RS03375 (TUZN_0705) | 608498..608896 | + | 399 | WP_013679531.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| TUZN_RS03380 (TUZN_0706) | 609144..610256 | - | 1113 | WP_013679532.1 | cytochrome ubiquinol oxidase subunit I | - |
| TUZN_RS03385 (TUZN_0707) | 610249..611892 | - | 1644 | WP_013679533.1 | cytochrome ubiquinol oxidase subunit I | - |
| TUZN_RS03390 (TUZN_0708) | 612055..612555 | + | 501 | WP_013679534.1 | helix-turn-helix domain-containing protein | - |
| TUZN_RS03395 (TUZN_0709) | 612585..613088 | + | 504 | WP_013679535.1 | metallophosphoesterase | - |
| TUZN_RS03400 (TUZN_0710) | 613085..613573 | + | 489 | WP_013679536.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14814.21 Da Isoelectric Point: 4.5727
>T25173 WP_013679531.1 NC_015315:608498-608896 [Thermoproteus uzoniensis 768-20]
MEIAADASAIAALFLPEDKSAVIEKLFGQAEAIHTLDLAAYEVLNAVWKYARRGVIGRRLAEEIETELLDLLRTLYIHRY
EEVLPDALKLALEKDVTVYDAAYVALAQKLGAPLLTLDRRLAEEFPRLAYMP
MEIAADASAIAALFLPEDKSAVIEKLFGQAEAIHTLDLAAYEVLNAVWKYARRGVIGRRLAEEIETELLDLLRTLYIHRY
EEVLPDALKLALEKDVTVYDAAYVALAQKLGAPLLTLDRRLAEEFPRLAYMP
Download Length: 399 bp
>T25173 NC_015315:608498-608896 [Thermoproteus uzoniensis 768-20]
ATGGAGATAGCCGCTGATGCCTCGGCTATCGCCGCCCTCTTCTTGCCGGAGGACAAAAGCGCCGTCATTGAGAAGCTGTT
CGGGCAGGCTGAGGCTATACATACGCTGGATCTAGCCGCCTACGAGGTGCTGAACGCAGTGTGGAAATACGCCAGGAGAG
GCGTTATAGGCAGGAGGCTAGCCGAGGAGATTGAGACGGAGCTTCTGGATCTGCTCAGGACCTTGTACATCCACCGCTAC
GAGGAGGTGCTTCCCGACGCCCTCAAGTTAGCCTTAGAAAAAGACGTCACTGTATACGACGCCGCATATGTGGCTCTTGC
CCAGAAGCTGGGCGCGCCTCTGTTGACGTTAGACAGGAGACTGGCCGAGGAGTTCCCCCGCCTGGCCTACATGCCCTAG
ATGGAGATAGCCGCTGATGCCTCGGCTATCGCCGCCCTCTTCTTGCCGGAGGACAAAAGCGCCGTCATTGAGAAGCTGTT
CGGGCAGGCTGAGGCTATACATACGCTGGATCTAGCCGCCTACGAGGTGCTGAACGCAGTGTGGAAATACGCCAGGAGAG
GCGTTATAGGCAGGAGGCTAGCCGAGGAGATTGAGACGGAGCTTCTGGATCTGCTCAGGACCTTGTACATCCACCGCTAC
GAGGAGGTGCTTCCCGACGCCCTCAAGTTAGCCTTAGAAAAAGACGTCACTGTATACGACGCCGCATATGTGGCTCTTGC
CCAGAAGCTGGGCGCGCCTCTGTTGACGTTAGACAGGAGACTGGCCGAGGAGTTCCCCCGCCTGGCCTACATGCCCTAG
Antitoxin
Download Length: 79 a.a. Molecular weight: 9222.45 Da Isoelectric Point: 8.7675
>AT25173 WP_013679530.1 NC_015315:608278-608514 [Thermoproteus uzoniensis 768-20]
VSEVISIRVRRELKRALEELGIDYAEEVRRFLEQLVARERRRRALERARSLREAVEREAGALPHVAELIREDRDGDSR
VSEVISIRVRRELKRALEELGIDYAEEVRRFLEQLVARERRRRALERARSLREAVEREAGALPHVAELIREDRDGDSR
Download Length: 237 bp
>AT25173 NC_015315:608278-608514 [Thermoproteus uzoniensis 768-20]
GTGAGCGAGGTTATCTCGATAAGGGTTAGAAGAGAGTTGAAAAGGGCGTTGGAGGAGCTGGGTATAGACTACGCCGAGGA
GGTCAGGAGGTTTCTGGAGCAACTTGTGGCTAGAGAGCGGAGGCGGAGGGCTCTGGAGAGGGCGCGGTCGCTGAGGGAAG
CTGTCGAGAGGGAGGCGGGCGCGTTGCCGCATGTCGCGGAGCTGATAAGGGAGGATAGAGATGGAGATAGCCGCTGA
GTGAGCGAGGTTATCTCGATAAGGGTTAGAAGAGAGTTGAAAAGGGCGTTGGAGGAGCTGGGTATAGACTACGCCGAGGA
GGTCAGGAGGTTTCTGGAGCAACTTGTGGCTAGAGAGCGGAGGCGGAGGGCTCTGGAGAGGGCGCGGTCGCTGAGGGAAG
CTGTCGAGAGGGAGGCGGGCGCGTTGCCGCATGTCGCGGAGCTGATAAGGGAGGATAGAGATGGAGATAGCCGCTGA