Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4251437..4251934 Replicon chromosome
Accession NZ_CP101263
Organism Escherichia coli strain EC21Z-063

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NML19_RS20760 Protein ID WP_001173343.1
Coordinates 4251437..4251610 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2U9LI53
Locus tag NML19_RS20765 Protein ID WP_071597404.1
Coordinates 4251638..4251934 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML19_RS20750 (4248102) 4248102..4249559 + 1458 WP_072778207.1 dipeptide/tripeptide permease DtpC -
NML19_RS20755 (4249796) 4249796..4251313 + 1518 WP_001295074.1 lysine--tRNA ligase -
NML19_RS20760 (4251437) 4251437..4251610 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NML19_RS20765 (4251638) 4251638..4251934 - 297 WP_071597404.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NML19_RS20770 (4252161) 4252161..4252433 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NML19_RS20775 (4252445) 4252445..4252675 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NML19_RS20780 (4252856) 4252856..4254487 + 1632 WP_001565376.1 sensor histidine kinase -
NML19_RS20785 (4254484) 4254484..4255203 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(6-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T251723 WP_001173343.1 NZ_CP101263:c4251610-4251437 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11495.99 Da        Isoelectric Point: 4.1705

>AT251723 WP_071597404.1 NZ_CP101263:c4251934-4251638 [Escherichia coli]
MEGKNRFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9LI53

References