Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4094344..4095158 | Replicon | chromosome |
| Accession | NZ_CP101263 | ||
| Organism | Escherichia coli strain EC21Z-063 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | NML19_RS19970 | Protein ID | WP_001054376.1 |
| Coordinates | 4094344..4094601 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | B7MMJ3 |
| Locus tag | NML19_RS19975 | Protein ID | WP_001338189.1 |
| Coordinates | 4094613..4095158 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NML19_RS19945 (4089632) | 4089632..4090738 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| NML19_RS19950 (4090803) | 4090803..4091783 | + | 981 | WP_000991455.1 | sialate O-acetylesterase | - |
| NML19_RS19955 (4091893) | 4091893..4092098 | + | 206 | Protein_3898 | HNH endonuclease | - |
| NML19_RS19960 (4092366) | 4092366..4093591 | - | 1226 | Protein_3899 | helicase YjhR | - |
| NML19_RS19965 (4093722) | 4093722..4093853 | + | 132 | WP_001309182.1 | hypothetical protein | - |
| NML19_RS19970 (4094344) | 4094344..4094601 | + | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
| NML19_RS19975 (4094613) | 4094613..4095158 | + | 546 | WP_001338189.1 | N-acetyltransferase | Antitoxin |
| NML19_RS19980 (4095214) | 4095214..4095960 | + | 747 | WP_078207781.1 | class I SAM-dependent methyltransferase | - |
| NML19_RS19985 (4096129) | 4096129..4096347 | + | 219 | Protein_3904 | hypothetical protein | - |
| NML19_RS19990 (4096385) | 4096385..4096501 | + | 117 | Protein_3905 | VOC family protein | - |
| NML19_RS19995 (4096746) | 4096746..4097867 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
| NML19_RS20000 (4097864) | 4097864..4098142 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
| NML19_RS20005 (4098154) | 4098154..4099467 | + | 1314 | WP_000460843.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimE / fimB | 4085767..4112373 | 26606 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T251722 WP_001054376.1 NZ_CP101263:4094344-4094601 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
Antitoxin
Download Length: 182 a.a. Molecular weight: 19986.92 Da Isoelectric Point: 6.3277
>AT251722 WP_001338189.1 NZ_CP101263:4094613-4095158 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PA82 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2KXJ3 |