Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3517514..3518132 Replicon chromosome
Accession NZ_CP101263
Organism Escherichia coli strain EC21Z-063

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML19_RS17250 Protein ID WP_001291435.1
Coordinates 3517914..3518132 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML19_RS17245 Protein ID WP_000344800.1
Coordinates 3517514..3517888 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML19_RS17235 (3512603) 3512603..3513796 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML19_RS17240 (3513819) 3513819..3516968 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML19_RS17245 (3517514) 3517514..3517888 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML19_RS17250 (3517914) 3517914..3518132 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML19_RS17255 (3518304) 3518304..3518855 + 552 WP_000102564.1 maltose O-acetyltransferase -
NML19_RS17260 (3518971) 3518971..3519441 + 471 WP_000136192.1 YlaC family protein -
NML19_RS17265 (3519605) 3519605..3521155 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML19_RS17270 (3521197) 3521197..3521550 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NML19_RS17280 (3521929) 3521929..3522240 + 312 WP_000409911.1 MGMT family protein -
NML19_RS17285 (3522271) 3522271..3522843 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251720 WP_001291435.1 NZ_CP101263:3517914-3518132 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251720 WP_000344800.1 NZ_CP101263:3517514-3517888 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References