Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 888578..889232 Replicon chromosome
Accession NZ_CP101263
Organism Escherichia coli strain EC21Z-063

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NML19_RS04345 Protein ID WP_000244777.1
Coordinates 888825..889232 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NML19_RS04340 Protein ID WP_000354046.1
Coordinates 888578..888844 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML19_RS04315 (883747) 883747..884490 + 744 WP_000951948.1 SDR family oxidoreductase -
NML19_RS04320 (884547) 884547..885980 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
NML19_RS04325 (886025) 886025..886336 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NML19_RS04330 (886500) 886500..887159 + 660 WP_000250274.1 hemolysin III family protein -
NML19_RS04335 (887355) 887355..888335 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NML19_RS04340 (888578) 888578..888844 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NML19_RS04345 (888825) 888825..889232 + 408 WP_000244777.1 protein YgfX Toxin
NML19_RS04350 (889272) 889272..889793 - 522 WP_001055874.1 flavodoxin FldB -
NML19_RS04355 (889905) 889905..890801 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NML19_RS04360 (890826) 890826..891536 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NML19_RS04365 (891542) 891542..893275 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T251711 WP_000244777.1 NZ_CP101263:888825-889232 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT251711 WP_000354046.1 NZ_CP101263:888578-888844 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References