Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1943..2490 Replicon plasmid pEC21Z078-85K
Accession NZ_CP101259
Organism Escherichia coli strain EC21Z-078

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NML20_RS23535 Protein ID WP_001384452.1
Coordinates 2212..2490 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag NML20_RS23530 Protein ID WP_032291093.1
Coordinates 1943..2212 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML20_RS23520 (1) 1..1032 + 1032 WP_048257187.1 plasmid replication initiator RepA -
NML20_RS23525 (1730) 1730..1888 + 159 WP_038349023.1 hypothetical protein -
NML20_RS23530 (1943) 1943..2212 + 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NML20_RS23535 (2212) 2212..2490 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NML20_RS23540 (2530) 2530..3378 + 849 WP_254825250.1 3'-5' exonuclease -
NML20_RS23545 (3694) 3694..4203 - 510 WP_032291091.1 hypothetical protein -
NML20_RS23550 (4259) 4259..4861 - 603 WP_000517687.1 ProQ/FINO family protein -
NML20_RS23555 (5214) 5214..6560 + 1347 WP_063118133.1 protein YagA -
NML20_RS23560 (7099) 7099..7401 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85299 85299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T251701 WP_001384452.1 NZ_CP101259:2212-2490 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT251701 WP_032291093.1 NZ_CP101259:1943-2212 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References