Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4283926..4284970 Replicon chromosome
Accession NZ_CP101257
Organism Escherichia coli strain EC21Z-078

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag NML20_RS20905 Protein ID WP_000019186.1
Coordinates 4283926..4284474 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag NML20_RS20910 Protein ID WP_000287252.1
Coordinates 4284497..4284970 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML20_RS20865 (4279250) 4279250..4279315 - 66 Protein_4076 phage minor tail protein L -
NML20_RS20870 (4279315) 4279315..4279689 - 375 Protein_4077 hypothetical protein -
NML20_RS20875 (4279733) 4279733..4279933 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
NML20_RS20880 (4280024) 4280024..4280698 + 675 WP_000859462.1 LexA family transcriptional repressor -
NML20_RS20885 (4281365) 4281365..4281727 + 363 WP_000135682.1 protein YfdP -
NML20_RS20890 (4281793) 4281793..4282617 + 825 WP_001753751.1 DUF2303 family protein -
NML20_RS20895 (4282792) 4282792..4283586 + 795 WP_001753750.1 hypothetical protein -
NML20_RS20900 (4283623) 4283623..4283892 + 270 WP_001093912.1 pyocin activator PrtN family protein -
NML20_RS20905 (4283926) 4283926..4284474 - 549 WP_000019186.1 hypothetical protein Toxin
NML20_RS20910 (4284497) 4284497..4284970 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
NML20_RS20915 (4285275) 4285275..4285379 - 105 Protein_4086 tRNA-dihydrouridine synthase -
NML20_RS20920 (4285742) 4285742..4286758 - 1017 WP_000912595.1 DUF2713 family protein -
NML20_RS20925 (4287076) 4287076..4287591 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
NML20_RS20930 (4287633) 4287633..4287842 - 210 WP_001030593.1 CsbD family protein -
NML20_RS20935 (4287958) 4287958..4289283 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
NML20_RS20940 (4289356) 4289356..4289964 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4268334..4289964 21630


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T251693 WP_000019186.1 NZ_CP101257:c4284474-4283926 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT251693 WP_000287252.1 NZ_CP101257:c4284970-4284497 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References