Detailed information of TA system TA025167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 4286069..4286579
• Replicon: chromosome
• Accession: NC_015276
• Organism: Marinomonas mediterranea MMB-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F2JYH1
• Locus tag: MARME_RS19555
• Protein ID: WP_013663002.1
• Coordinates: 4286069..4286332 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F2JYH2
• Locus tag: MARME_RS19560
• Protein ID: WP_013663003.1
• Coordinates: 4286325..4286579 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MARME_RS19525	4281136..4281338	-	203	Protein_3828	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MARME_RS21670	4281641..4283188	+	1548	WP_013662997.1	hypothetical protein	-
MARME_RS19535	4283198..4283671	-	474	WP_013662998.1	hypothetical protein	-
MARME_RS19540	4283852..4285018	+	1167	WP_013662999.1	cell division protein ZapE	-
MARME_RS19545	4285202..4285645	-	444	WP_013663000.1	GNAT family N-acetyltransferase	-
MARME_RS19550	4285709..4285966	-	258	Protein_3833	hypothetical protein	-
MARME_RS19555	4286069..4286332	-	264	WP_013663002.1	Txe/YoeB family addiction module toxin	Toxin
MARME_RS19560	4286325..4286579	-	255	WP_013663003.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MARME_RS19565	4286681..4287202	-	522	WP_013663004.1	DUF2569 domain-containing protein	-
MARME_RS19570	4287719..4289200	-	1482	WP_013663005.1	carboxypeptidase M32	-
MARME_RS19575	4289490..4290356	+	867	WP_013663006.1	DMT family transporter	-
MARME_RS21675	4290441..4290890	+	450	WP_013663007.1	hypothetical protein	-
MARME_RS19585	4290878..4291408	+	531	WP_013663008.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10256.69 Da
• Isoelectric Point: 9.4082

>T25167 WP_013663002.1 NC_015276:c4286332-4286069 [Marinomonas mediterranea MMB-1]
MSDRLLSWTDEAWNGYVYWQTQDKKTLKRINKLIADVKRSPFVGIGKPESLKENLSGFWSRRIDDTNRLVYAVDDIAITV
ISCRYHY

Nucleotide

• Length: 264 bp

>T25167 NC_015276:c4286332-4286069 [Marinomonas mediterranea MMB-1]
ATGAGTGACAGGTTATTATCATGGACTGATGAAGCTTGGAATGGTTACGTCTATTGGCAGACTCAAGACAAGAAAACATT
GAAACGAATCAATAAGCTAATTGCCGATGTTAAGCGCTCTCCATTTGTTGGGATTGGAAAACCAGAGTCCCTTAAAGAAA
ACCTTTCAGGCTTCTGGTCTCGCAGAATAGATGATACCAATCGTTTGGTATATGCCGTGGATGATATAGCAATTACGGTT
ATCTCGTGTCGGTATCATTACTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9480.67 Da
• Isoelectric Point: 5.0623

>AT25167 WP_013663003.1 NC_015276:c4286579-4286325 [Marinomonas mediterranea MMB-1]
MRIVSFTEARNGLKAVLDNVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKTTQRE
LIDE

Nucleotide

• Length: 255 bp

>AT25167 NC_015276:c4286579-4286325 [Marinomonas mediterranea MMB-1]
ATGAGAATAGTCTCTTTTACCGAAGCCCGAAATGGCCTAAAAGCCGTTTTGGACAATGTAATTAACGATGCGGATACTAC
TGTAATCACTCGTCGTGACTCTGAAGATGCTGTTGTAATGTCATTGGATTACTACAACAGCCTTATGGAAACTGTTCATT
TACTTCGTTCTCCAGCTAACGCTGAACACTTAAATCGTTCAATTGCACAGTTTAAAGCGGGTAAAACGACCCAGCGAGAG
CTTATTGATGAGTGA

Structures

Toxin

• AlphaFold DB: F2JYH1

Antitoxin

• AlphaFold DB: F2JYH2