Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4284029..4285073 Replicon chromosome
Accession NZ_CP101251
Organism Escherichia coli strain EC21Z-083

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag NML21_RS20875 Protein ID WP_000019186.1
Coordinates 4284029..4284577 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag NML21_RS20880 Protein ID WP_000287252.1
Coordinates 4284600..4285073 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML21_RS20835 (4279353) 4279353..4279418 - 66 Protein_4070 phage minor tail protein L -
NML21_RS20840 (4279418) 4279418..4279792 - 375 Protein_4071 hypothetical protein -
NML21_RS20845 (4279836) 4279836..4280036 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
NML21_RS20850 (4280127) 4280127..4280801 + 675 WP_000859462.1 LexA family transcriptional repressor -
NML21_RS20855 (4281468) 4281468..4281830 + 363 WP_000135680.1 protein YfdP -
NML21_RS20860 (4281896) 4281896..4282720 + 825 WP_001753751.1 DUF2303 family protein -
NML21_RS20865 (4282907) 4282907..4283689 + 783 WP_000610754.1 hypothetical protein -
NML21_RS20870 (4283726) 4283726..4283995 + 270 WP_001093912.1 pyocin activator PrtN family protein -
NML21_RS20875 (4284029) 4284029..4284577 - 549 WP_000019186.1 hypothetical protein Toxin
NML21_RS20880 (4284600) 4284600..4285073 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
NML21_RS20885 (4285378) 4285378..4285482 - 105 Protein_4080 tRNA-dihydrouridine synthase -
NML21_RS20890 (4285845) 4285845..4286861 - 1017 WP_000912595.1 DUF2713 family protein -
NML21_RS20895 (4287179) 4287179..4287694 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
NML21_RS20900 (4287736) 4287736..4287945 - 210 WP_001030593.1 CsbD family protein -
NML21_RS20905 (4288061) 4288061..4289386 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
NML21_RS20910 (4289459) 4289459..4290067 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4268437..4290067 21630


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T251664 WP_000019186.1 NZ_CP101251:c4284577-4284029 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT251664 WP_000287252.1 NZ_CP101251:c4285073-4284600 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References