Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877362..878016 Replicon chromosome
Accession NZ_CP101251
Organism Escherichia coli strain EC21Z-083

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NML21_RS04285 Protein ID WP_000244777.1
Coordinates 877609..878016 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NML21_RS04280 Protein ID WP_000354046.1
Coordinates 877362..877628 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML21_RS04255 (872650) 872650..873393 + 744 Protein_834 SDR family oxidoreductase -
NML21_RS04260 (873450) 873450..874883 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NML21_RS04265 (874928) 874928..875239 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
NML21_RS04270 (875403) 875403..876062 + 660 WP_000250274.1 hemolysin III family protein -
NML21_RS04275 (876139) 876139..877119 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NML21_RS04280 (877362) 877362..877628 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NML21_RS04285 (877609) 877609..878016 + 408 WP_000244777.1 protein YgfX Toxin
NML21_RS04290 (878056) 878056..878577 - 522 WP_001055874.1 flavodoxin FldB -
NML21_RS04295 (878689) 878689..879585 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NML21_RS04300 (879610) 879610..880320 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NML21_RS04305 (880326) 880326..882059 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T251653 WP_000244777.1 NZ_CP101251:877609-878016 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT251653 WP_000354046.1 NZ_CP101251:877362-877628 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References