Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3415423..3416041 Replicon chromosome
Accession NZ_CP101245
Organism Escherichia coli strain EC21Z-097

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML22_RS16635 Protein ID WP_001291435.1
Coordinates 3415823..3416041 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML22_RS16630 Protein ID WP_000344800.1
Coordinates 3415423..3415797 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML22_RS16620 (3410512) 3410512..3411705 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML22_RS16625 (3411728) 3411728..3414877 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML22_RS16630 (3415423) 3415423..3415797 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML22_RS16635 (3415823) 3415823..3416041 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML22_RS16640 (3416213) 3416213..3416764 + 552 WP_000102568.1 maltose O-acetyltransferase -
NML22_RS16645 (3416880) 3416880..3417350 + 471 WP_000136192.1 YlaC family protein -
NML22_RS16650 (3417514) 3417514..3419064 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML22_RS16655 (3419106) 3419106..3419459 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NML22_RS16665 (3419838) 3419838..3420149 + 312 WP_000409911.1 MGMT family protein -
NML22_RS16670 (3420180) 3420180..3420752 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251633 WP_001291435.1 NZ_CP101245:3415823-3416041 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251633 WP_000344800.1 NZ_CP101245:3415423-3415797 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References