Detailed information of TA system TA025163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 938131..938696
• Replicon: chromosome
• Accession: NC_015259
• Organism: Polymorphum gilvum SL003B-26A1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: F2IX12
• Locus tag: SL003B_RS04435
• Protein ID: WP_013651621.1
• Coordinates: 938403..938696 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F2IX11
• Locus tag: SL003B_RS04430
• Protein ID: WP_013651620.1
• Coordinates: 938131..938415 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SL003B_RS04420	934475..935977	-	1503	WP_013651617.1	sigma-54 dependent transcriptional regulator	-
SL003B_RS04425	936184..937998	+	1815	WP_013651619.1	M3 family oligoendopeptidase	-
SL003B_RS04430	938131..938415	+	285	WP_013651620.1	ribbon-helix-helix protein, CopG family	Antitoxin
SL003B_RS04435	938403..938696	+	294	WP_013651621.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SL003B_RS04440	939024..939938	+	915	WP_013651623.1	DUF3445 domain-containing protein	-
SL003B_RS04445	940051..941430	+	1380	WP_013651624.1	AarF/ABC1/UbiB kinase family protein	-
SL003B_RS04450	941550..941831	+	282	WP_041375374.1	aa3-type cytochrome c oxidase subunit IV	-
SL003B_RS04455	941951..942622	+	672	WP_013651626.1	RNA pseudouridine synthase	-
SL003B_RS04460	942703..943524	-	822	WP_013651627.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10854.50 Da
• Isoelectric Point: 8.9687

>T25163 WP_013651621.1 NC_015259:938403-938696 [Polymorphum gilvum SL003B-26A1]
MPRLIWTPEALRDVQRCYRFLALRNPAAASRAVRAIREEMQVVAAHPGAGRPVETMDPAFREWLIGFGDSGYVALYRLDG
DVAVVLAVRHQKEAGYS

Nucleotide

• Length: 294 bp

>T25163 NC_015259:938403-938696 [Polymorphum gilvum SL003B-26A1]
ATGCCGCGATTGATCTGGACGCCGGAAGCCCTGCGGGACGTCCAGCGCTGCTACCGCTTCCTCGCCTTGAGGAACCCCGC
CGCCGCGTCCCGTGCCGTGCGGGCGATACGCGAGGAAATGCAGGTGGTGGCGGCGCATCCCGGCGCGGGGCGCCCGGTCG
AGACGATGGATCCGGCGTTCCGGGAATGGCTGATTGGTTTTGGCGACAGCGGCTATGTCGCGCTGTACCGGCTGGACGGC
GATGTGGCGGTGGTCCTGGCCGTCCGCCACCAGAAAGAAGCGGGGTATTCCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10784.06 Da
• Isoelectric Point: 6.3283

>AT25163 WP_013651620.1 NC_015259:938131-938415 [Polymorphum gilvum SL003B-26A1]
MPAAHPVTVKLDPDVHDRVRQLAKAQRRSAHFLMREAITQYVEREEKREALRQDAMTAWGAYQATGRHVPHAEADDWLAR
LEAGEDVDPPQCRD

Nucleotide

• Length: 285 bp

>AT25163 NC_015259:938131-938415 [Polymorphum gilvum SL003B-26A1]
ATGCCTGCTGCCCATCCCGTCACCGTGAAGCTCGATCCGGATGTTCACGATCGGGTCCGCCAGCTCGCCAAGGCGCAGCG
CCGCTCCGCGCATTTCCTGATGCGCGAGGCGATCACCCAGTATGTCGAGCGCGAGGAAAAGCGCGAGGCGCTCAGGCAAG
ATGCGATGACCGCCTGGGGAGCCTATCAGGCGACCGGTCGGCACGTCCCCCACGCCGAGGCTGATGACTGGCTGGCGCGG
CTCGAGGCTGGGGAGGACGTGGACCCGCCGCAATGCCGCGATTGA

Structures

Toxin

• AlphaFold DB: F2IX12

Antitoxin

• AlphaFold DB: F2IX11