Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1822..2357 Replicon plasmid pEC21Z137-66K
Accession NZ_CP101237
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag NML24_RS24430 Protein ID WP_000222766.1
Coordinates 2070..2357 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag NML24_RS24425 Protein ID WP_001132900.1
Coordinates 1822..2073 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS24420 (1) 1..858 + 858 WP_141035014.1 incFII family plasmid replication initiator RepA -
NML24_RS24425 (1822) 1822..2073 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NML24_RS24430 (2070) 2070..2357 + 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML24_RS24435 (2626) 2626..3114 - 489 Protein_3 IS3 family transposase -
NML24_RS24440 (3167) 3167..3871 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NML24_RS24445 (3936) 3936..4592 + 657 Protein_5 IS4-like element ISVsa5 family transposase -
NML24_RS24450 (4605) 4605..5222 - 618 Protein_6 IS6-like element IS26 family transposase -
NML24_RS24455 (5287) 5287..5943 + 657 Protein_7 IS4-like element ISVsa5 family transposase -
NML24_RS24460 (5956) 5956..6573 - 618 Protein_8 IS6-like element IS26 family transposase -
NML24_RS24465 (6564) 6564..7070 + 507 WP_001505085.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..65831 65831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T251595 WP_000222766.1 NZ_CP101237:2070-2357 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT251595 WP_001132900.1 NZ_CP101237:1822-2073 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References