Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 40551..41149 Replicon plasmid pEC21Z137-115K
Accession NZ_CP101235
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NML24_RS23470 Protein ID WP_032187669.1
Coordinates 40772..41149 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID L4J1C0
Locus tag NML24_RS23465 Protein ID WP_001603498.1
Coordinates 40551..40772 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS23445 (NML24_23410) 35557..36105 + 549 WP_032187673.1 fimbrial protein YehD -
NML24_RS23450 (NML24_23415) 36161..36841 + 681 WP_032187672.1 fimbrial assembly chaperone -
NML24_RS23455 (NML24_23420) 36859..39345 + 2487 WP_212403473.1 fimbrial biogenesis outer membrane usher protein -
NML24_RS23460 (NML24_23425) 39356..40366 + 1011 WP_254841647.1 fimbrial protein -
NML24_RS23465 (NML24_23430) 40551..40772 + 222 WP_001603498.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NML24_RS23470 (NML24_23435) 40772..41149 + 378 WP_032187669.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NML24_RS23475 (NML24_23440) 41283..42467 - 1185 WP_050489703.1 DNA primase -
NML24_RS23480 (NML24_23445) 42555..43895 - 1341 WP_023135655.1 DnaB-like helicase C-terminal domain-containing protein -
NML24_RS23485 (NML24_23450) 43956..44681 - 726 WP_087904723.1 hypothetical protein -
NML24_RS23490 (NML24_23455) 44964..45731 + 768 WP_001711193.1 hypothetical protein -
NML24_RS23495 (NML24_23460) 45784..46137 - 354 WP_160378290.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115200 115200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13465.18 Da        Isoelectric Point: 6.2257

>T251592 WP_032187669.1 NZ_CP101235:40772-41149 [Escherichia coli]
MRHISPEELTAIHDANISRYGGLPGMSDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8190.24 Da        Isoelectric Point: 6.3159

>AT251592 WP_001603498.1 NZ_CP101235:40551-40772 [Escherichia coli]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J1C0

References