Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4062505..4063002 Replicon chromosome
Accession NZ_CP101233
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NML24_RS19860 Protein ID WP_001173343.1
Coordinates 4062505..4062678 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NML24_RS19865 Protein ID WP_000398619.1
Coordinates 4062706..4063002 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS19850 (4059175) 4059175..4060632 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NML24_RS19855 (4060869) 4060869..4062386 + 1518 WP_001295074.1 lysine--tRNA ligase -
NML24_RS19860 (4062505) 4062505..4062678 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NML24_RS19865 (4062706) 4062706..4063002 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NML24_RS19870 (4063229) 4063229..4063501 - 273 WP_096991230.1 GNAT family N-acetyltransferase -
NML24_RS19875 (4063513) 4063513..4063743 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NML24_RS19880 (4063924) 4063924..4065555 + 1632 WP_001216477.1 sensor histidine kinase -
NML24_RS19885 (4065552) 4065552..4066271 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T251590 WP_001173343.1 NZ_CP101233:c4062678-4062505 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT251590 WP_000398619.1 NZ_CP101233:c4063002-4062706 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References