Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3324472..3325090 Replicon chromosome
Accession NZ_CP101233
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML24_RS16150 Protein ID WP_001291435.1
Coordinates 3324872..3325090 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML24_RS16145 Protein ID WP_000344800.1
Coordinates 3324472..3324846 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS16135 (3319561) 3319561..3320754 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML24_RS16140 (3320777) 3320777..3323926 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML24_RS16145 (3324472) 3324472..3324846 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML24_RS16150 (3324872) 3324872..3325090 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML24_RS16155 (3325262) 3325262..3325813 + 552 WP_000102564.1 maltose O-acetyltransferase -
NML24_RS16160 (3325929) 3325929..3326399 + 471 WP_000136192.1 YlaC family protein -
NML24_RS16165 (3326563) 3326563..3328113 + 1551 WP_077477703.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML24_RS16170 (3328155) 3328155..3328508 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NML24_RS16180 (3328887) 3328887..3329198 + 312 WP_000409911.1 MGMT family protein -
NML24_RS16185 (3329229) 3329229..3329801 - 573 WP_077477690.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251588 WP_001291435.1 NZ_CP101233:3324872-3325090 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251588 WP_000344800.1 NZ_CP101233:3324472-3324846 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References