Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 936827..937410 Replicon chromosome
Accession NZ_CP101233
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag NML24_RS04610 Protein ID WP_000254738.1
Coordinates 937075..937410 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag NML24_RS04605 Protein ID WP_000581937.1
Coordinates 936827..937075 (+) Length 83 a.a.

Genomic Context


NML24_RS04595NML24_RS04600NML24_RS04605NML24_RS04610NML24_RS04615NML24_RS04620NML24_RS04625
Location: 933166..934467 (1302 bp)
Type: Others
Protein ID: WP_000046812.1
Location: 934515..936749 (2235 bp)
Type: Others
Protein ID: WP_000226815.1
Location: 936827..937075 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1
Location: 937075..937410 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Location: 937481..938272 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Location: 938500..940137 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Location: 940225..941523 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NML24_RS04595 (933166)933166..934467+1302WP_000046812.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-
NML24_RS04600 (934515)934515..936749+2235WP_000226815.1GTP pyrophosphokinase-
NML24_RS04605 (936827)936827..937075+249WP_000581937.1type II toxin-antitoxin system antitoxin MazEAntitoxin
NML24_RS04610 (937075)937075..937410+336WP_000254738.1endoribonuclease MazFToxin
NML24_RS04615 (937481)937481..938272+792WP_001071648.1nucleoside triphosphate pyrophosphohydrolase-
NML24_RS04620 (938500)938500..940137+1638WP_000210878.1CTP synthase (glutamine hydrolyzing)-
NML24_RS04625 (940225)940225..941523+1299WP_000036723.1phosphopyruvate hydratase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-109)

Antitoxin

(7-51)


Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T251581 WP_000254738.1 NZ_CP101233:937075-937410 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp


Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT251581 WP_000581937.1 NZ_CP101233:936827-937075 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CK9
PDB5CKH
PDB5CO7
PDB3NFC
PDB5CR2
PDB5CKB
PDB5CQY
PDB5CKD
PDB5CKE
PDB5CKF


Antitoxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CQY
PDB1MVF
PDB2MRN
PDB2MRU
AlphaFold DBA0A7U9LMB4

References