Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 936827..937410 | Replicon | chromosome |
Accession | NZ_CP101233 | ||
Organism | Escherichia coli strain EC21Z-137 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | NML24_RS04610 | Protein ID | WP_000254738.1 |
Coordinates | 937075..937410 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | NML24_RS04605 | Protein ID | WP_000581937.1 |
Coordinates | 936827..937075 (+) | Length | 83 a.a. |
Genomic Context
Location: 933166..934467 (1302 bp)
Type: Others
Protein ID: WP_000046812.1
Type: Others
Protein ID: WP_000046812.1
Location: 934515..936749 (2235 bp)
Type: Others
Protein ID: WP_000226815.1
Type: Others
Protein ID: WP_000226815.1
Location: 936827..937075 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1
Type: Antitoxin
Protein ID: WP_000581937.1
Location: 937075..937410 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Type: Toxin
Protein ID: WP_000254738.1
Location: 937481..938272 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Type: Others
Protein ID: WP_001071648.1
Location: 938500..940137 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Type: Others
Protein ID: WP_000210878.1
Location: 940225..941523 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
Type: Others
Protein ID: WP_000036723.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NML24_RS04595 (933166) | 933166..934467 | + | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
NML24_RS04600 (934515) | 934515..936749 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
NML24_RS04605 (936827) | 936827..937075 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
NML24_RS04610 (937075) | 937075..937410 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
NML24_RS04615 (937481) | 937481..938272 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
NML24_RS04620 (938500) | 938500..940137 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
NML24_RS04625 (940225) | 940225..941523 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T251581 WP_000254738.1 NZ_CP101233:937075-937410 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp