Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4467436..4468079 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag YE105_RS20175 Protein ID WP_005161957.1
Coordinates 4467436..4467855 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag YE105_RS20180 Protein ID WP_005161959.1
Coordinates 4467852..4468079 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS20155 4462494..4463348 + 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -
YE105_RS20160 4463475..4464098 + 624 WP_013650637.1 superoxide dismutase [Mn] -
YE105_RS20165 4464583..4466532 + 1950 WP_013650638.1 methyl-accepting chemotaxis protein -
YE105_RS20170 4466611..4467282 + 672 WP_005161954.1 6-N-hydroxylaminopurine resistance protein -
YE105_RS20175 4467436..4467855 - 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
YE105_RS20180 4467852..4468079 - 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
YE105_RS20185 4468211..4468567 - 357 WP_005161962.1 YibL family ribosome-associated protein -
YE105_RS20190 4468660..4470141 - 1482 WP_013650640.1 PLP-dependent aminotransferase family protein -
YE105_RS20195 4470409..4471020 + 612 WP_013650641.1 LysE family translocator -
YE105_RS20200 4471017..4471571 - 555 WP_020283571.1 MltR family transcriptional regulator -
YE105_RS20205 4471802..4472965 - 1164 WP_013650643.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T25158 WP_005161957.1 NC_015224:c4467855-4467436 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T25158 NC_015224:c4467855-4467436 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCCGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT25158 WP_005161959.1 NC_015224:c4468079-4467852 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT25158 NC_015224:c4468079-4467852 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References