Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1781..2328 Replicon plasmid pEC21Z144-85K
Accession NZ_CP101225
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NML25_RS26035 Protein ID WP_013009346.1
Coordinates 2050..2328 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag NML25_RS26030 Protein ID WP_000079932.1
Coordinates 1781..2050 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS26020 (NML25_26015) 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
NML25_RS26025 (NML25_26020) 1568..1726 + 159 WP_000829588.1 hypothetical protein -
NML25_RS26030 (NML25_26025) 1781..2050 + 270 WP_000079932.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NML25_RS26035 (NML25_26030) 2050..2328 + 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
NML25_RS26040 (NML25_26035) 2524..2820 - 297 WP_001419651.1 hypothetical protein -
NML25_RS26045 (NML25_26040) 3165..3752 + 588 WP_001418189.1 serine acetyltransferase -
NML25_RS26050 (NML25_26045) 4034..4627 - 594 WP_001401779.1 ProQ/FINO family protein -
NML25_RS26055 (NML25_26050) 4981..6072 + 1092 Protein_7 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85147 85147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T251574 WP_013009346.1 NZ_CP101225:2050-2328 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT251574 WP_000079932.1 NZ_CP101225:1781-2050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References