Detailed information of TA system TA025157

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4404760..4405344
• Replicon: chromosome
• Accession: NC_015224
• Organism: Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7U7ISC5
• Locus tag: YE105_RS19940
• Protein ID: WP_005165296.1
• Coordinates: 4404976..4405344 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: YE105_RS22140
• Protein ID: WP_129019424.1
• Coordinates: 4404760..4404912 (+)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE105_RS19925	4400212..4401618	+	1407	WP_013650609.1	filamentous hemagglutinin N-terminal domain-containing protein	-
YE105_RS19930	4401851..4403314	-	1464	WP_005166182.1	alpha/beta hydrolase	-
YE105_RS19935	4403489..4404691	-	1203	WP_005176946.1	IS256 family transposase	-
YE105_RS22140	4404760..4404912	+	153	WP_129019424.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
YE105_RS19940	4404976..4405344	+	369	WP_005165296.1	TA system toxin CbtA family protein	Toxin
YE105_RS19945	4405573..4406433	+	861	WP_013650611.1	DUF4942 domain-containing protein	-
YE105_RS19950	4406470..4407495	+	1026	WP_080007222.1	IS110 family transposase	-
YE105_RS19955	4409040..4409513	+	474	WP_005165291.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4400212..4409513	9301
	-	inside	IScluster/Tn	-	-	4403489..4407495	4006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (1-45)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13609.55 Da
• Isoelectric Point: 6.4731

>T25157 WP_005165296.1 NC_015224:4404976-4405344 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MQTLPVTSKRAAYACLSPVIVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLARTDHRGF
SCQEQSPFITSIDILRARRATGLMTRMGYQTITSVIRGGKQA

Nucleotide

• Length: 369 bp

>T25157 NC_015224:4404976-4405344 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGCAGACCTTACCTGTCACCTCGAAACGGGCGGCCTACGCTTGCCTATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTAGAGCAGCATTACGGCCTGGTGCTTAGCGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGCTGAATTTCACGGTGGAGAAGTTTGACTTGGCTCGCACCGATCACCGAGGTTTC
TCCTGCCAGGAACAATCTCCCTTTATCACGTCTATCGATATTCTCCGCGCTCGTCGAGCCACCGGTCTGATGACCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGGAAAGCAGGCATGA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5593.44 Da
• Isoelectric Point: 4.5803

>AT25157 WP_129019424.1 NC_015224:4404760-4404912 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MELMLLSGELNPRYQHCVTLYRNGLICEADSLGSQGYVYLAIYPTPQSIA

Nucleotide

• Length: 153 bp

>AT25157 NC_015224:4404760-4404912 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
CTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGCGTCACGTTGTATCGCAATGGCTTGATCTG
CGAAGCCGATAGCCTGGGATCACAGGGTTATGTGTATCTCGCCATTTATCCTACTCCCCAATCAATTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7ISC5