Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4766903..4767515 Replicon chromosome
Accession NZ_CP101222
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NML25_RS22980 Protein ID WP_000833473.1
Coordinates 4767330..4767515 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NML25_RS22975 Protein ID WP_000499744.1
Coordinates 4766903..4767313 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS22960 (4762415) 4762415..4763230 - 816 WP_000891823.1 AraC family transcriptional regulator -
NML25_RS22965 (4763456) 4763456..4764856 + 1401 WP_000204811.1 MFS transporter -
NML25_RS22970 (4764867) 4764867..4766831 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
NML25_RS22975 (4766903) 4766903..4767313 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NML25_RS22980 (4767330) 4767330..4767515 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NML25_RS22985 (4767784) 4767784..4769322 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
NML25_RS22990 (4769523) 4769523..4770674 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T251563 WP_000833473.1 NZ_CP101222:c4767515-4767330 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT251563 WP_000499744.1 NZ_CP101222:c4767313-4766903 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References