Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4094025..4095654 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U7IQ60
Locus tag YE105_RS18605 Protein ID WP_005165219.1
Coordinates 4094326..4095654 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A7U7FJW4
Locus tag YE105_RS18600 Protein ID WP_005165217.1
Coordinates 4094025..4094324 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS18585 4089472..4091121 - 1650 WP_020282670.1 Na+/H+ antiporter -
YE105_RS18590 4091331..4092698 - 1368 WP_005165212.1 NCS2 family permease -
YE105_RS18595 4093059..4093730 - 672 WP_013650521.1 glutathione S-transferase -
YE105_RS18600 4094025..4094324 + 300 WP_005165217.1 helix-turn-helix transcriptional regulator Antitoxin
YE105_RS18605 4094326..4095654 + 1329 WP_005165219.1 type II toxin-antitoxin system HipA family toxin Toxin
YE105_RS18610 4095743..4096291 - 549 WP_005165221.1 single-stranded DNA-binding protein SSB1 -
YE105_RS18615 4096820..4099651 + 2832 WP_013650522.1 excinuclease ABC subunit UvrA -
YE105_RS18620 4099710..4100063 - 354 WP_005165225.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49925.93 Da        Isoelectric Point: 6.8736

>T25156 WP_005165219.1 NC_015224:4094326-4095654 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAVQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Download         Length: 1329 bp

>T25156 NC_015224:4094326-4095654 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCACGTTGGCTATTGGGAAAAAAATCGAGGCGAAGA
ATCGCTGGTTTATGCCCAAGAATGGTTAGCAAACGAACAAGGCCGACCGCTATCATTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATACCACGCTGACAGCATTAACCCTTTCGATCTATTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TTCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTCGCCAGTTGTGAAATTGGCCAGTTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGTTTATCGCGTGACAAGAGTTGGATCGTCAGATTACCGCAAGAAGATATGTGCCAGGCCACTGGGACTTCTCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCAGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACGTCTTCTTTAAAGCACAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTGCTCATCTCCCCGGGAGTCGTTATCACCTCACGCCACTTTATGACGTGTTATCAACCCATCCGATTATCGGCTCGGG
TCGTAATCAGATTGCGGTTCAAAAATCCAAGTTAGCGATGGCGGTAAGAGGGAGTAAAAATTACTATTTGATTAACCAGA
TCCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATCGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCTCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGAGAAAAT
CCTTACTGGCCTTCATAAACAATGTGAAAAAATCTCGGCAATGCTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11141.78 Da        Isoelectric Point: 8.5374

>AT25156 WP_005165217.1 NC_015224:4094025-4094324 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILSEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp

>AT25156 NC_015224:4094025-4094324 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGAATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCACCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTAGTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IQ60

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJW4

References