Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2285964..2286602 Replicon chromosome
Accession NZ_CP101222
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NML25_RS11030 Protein ID WP_000813795.1
Coordinates 2285964..2286140 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NML25_RS11035 Protein ID WP_076797675.1
Coordinates 2286186..2286602 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS11010 (2281586) 2281586..2282758 - 1173 WP_001551088.1 BenE family transporter YdcO -
NML25_RS11015 (2282850) 2282850..2283386 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NML25_RS11020 (2283459) 2283459..2285420 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NML25_RS11025 (2285512) 2285512..2285742 - 231 WP_023910283.1 YncJ family protein -
NML25_RS11030 (2285964) 2285964..2286140 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NML25_RS11035 (2286186) 2286186..2286602 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NML25_RS11040 (2286681) 2286681..2288087 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NML25_RS11045 (2288332) 2288332..2289477 + 1146 Protein_2150 ABC transporter substrate-binding protein -
NML25_RS11050 (2289495) 2289495..2290508 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NML25_RS11055 (2290509) 2290509..2291450 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T251551 WP_000813795.1 NZ_CP101222:2285964-2286140 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT251551 WP_076797675.1 NZ_CP101222:2286186-2286602 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References