Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1595856..1596561 Replicon chromosome
Accession NZ_CP101222
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NML25_RS07460 Protein ID WP_000539521.1
Coordinates 1596175..1596561 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NML25_RS07455 Protein ID WP_001280945.1
Coordinates 1595856..1596185 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS07440 (1591013) 1591013..1591924 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
NML25_RS07445 (1592102) 1592102..1594450 + 2349 WP_001550886.1 EAL domain-containing protein -
NML25_RS07450 (1594458) 1594458..1595786 + 1329 WP_001550887.1 GGDEF domain-containing protein -
NML25_RS07455 (1595856) 1595856..1596185 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NML25_RS07460 (1596175) 1596175..1596561 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML25_RS07465 (1596787) 1596787..1598112 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NML25_RS07470 (1598325) 1598325..1598708 + 384 WP_000497137.1 biofilm formation regulator BssR -
NML25_RS07475 (1598819) 1598819..1599934 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NML25_RS07480 (1599931) 1599931..1600557 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T251548 WP_000539521.1 NZ_CP101222:c1596561-1596175 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT251548 WP_001280945.1 NZ_CP101222:c1596185-1595856 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References