Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 455402..455997 Replicon chromosome
Accession NZ_CP101222
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag NML25_RS02210 Protein ID WP_019842229.1
Coordinates 455647..455997 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NML25_RS02205 Protein ID WP_001223213.1
Coordinates 455402..455653 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS02195 (451067) 451067..454846 + 3780 WP_001596432.1 autotransporter assembly complex protein TamB -
NML25_RS02200 (454849) 454849..455190 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
NML25_RS02205 (455402) 455402..455653 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NML25_RS02210 (455647) 455647..455997 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
NML25_RS02215 (456201) 456201..456731 - 531 WP_000055075.1 inorganic diphosphatase -
NML25_RS02220 (457041) 457041..457997 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NML25_RS02225 (458129) 458129..459631 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
NML25_RS02230 (459645) 459645..460667 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T251543 WP_019842229.1 NZ_CP101222:455647-455997 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT251543 WP_001223213.1 NZ_CP101222:455402-455653 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References