Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4563384..4563881 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NML26_RS22355 Protein ID WP_001173343.1
Coordinates 4563384..4563557 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag NML26_RS22360 Protein ID WP_001317561.1
Coordinates 4563585..4563881 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS22345 (4560054) 4560054..4561511 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
NML26_RS22350 (4561748) 4561748..4563265 + 1518 WP_000003805.1 lysine--tRNA ligase -
NML26_RS22355 (4563384) 4563384..4563557 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NML26_RS22360 (4563585) 4563585..4563881 - 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NML26_RS22365 (4564108) 4564108..4564380 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NML26_RS22370 (4564392) 4564392..4564622 - 231 WP_000371717.1 4Fe-4S mono-cluster protein YjdI -
NML26_RS22375 (4564802) 4564802..4566433 + 1632 WP_001216477.1 sensor histidine kinase -
NML26_RS22380 (4566430) 4566430..4567149 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T251528 WP_001173343.1 NZ_CP101210:c4563557-4563384 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT251528 WP_001317561.1 NZ_CP101210:c4563881-4563585 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References