Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3661765..3662383 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML26_RS18035 Protein ID WP_001291435.1
Coordinates 3662165..3662383 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8S7S0Y3
Locus tag NML26_RS18030 Protein ID WP_039004128.1
Coordinates 3661765..3662139 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS18020 (3656854) 3656854..3658047 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML26_RS18025 (3658070) 3658070..3661219 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NML26_RS18030 (3661765) 3661765..3662139 + 375 WP_039004128.1 Hha toxicity modulator TomB Antitoxin
NML26_RS18035 (3662165) 3662165..3662383 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML26_RS18040 (3662555) 3662555..3663106 + 552 WP_000102564.1 maltose O-acetyltransferase -
NML26_RS18045 (3663222) 3663222..3663692 + 471 WP_000136192.1 YlaC family protein -
NML26_RS18050 (3663856) 3663856..3665406 + 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML26_RS18055 (3665448) 3665448..3665801 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NML26_RS18065 (3666180) 3666180..3666491 + 312 WP_000409911.1 MGMT family protein -
NML26_RS18070 (3666522) 3666522..3667094 - 573 WP_000779821.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251523 WP_001291435.1 NZ_CP101210:3662165-3662383 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT251523 WP_039004128.1 NZ_CP101210:3661765-3662139 [Escherichia coli]
MDEYSPKRHDITQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References