Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3243577..3244282 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NML26_RS15860 Protein ID WP_000539521.1
Coordinates 3243577..3243963 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NML26_RS15865 Protein ID WP_001280945.1
Coordinates 3243953..3244282 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS15840 (3239581) 3239581..3240207 + 627 WP_001295292.1 glutathione S-transferase GstB -
NML26_RS15845 (3240204) 3240204..3241319 - 1116 WP_000555041.1 aldose sugar dehydrogenase YliI -
NML26_RS15850 (3241430) 3241430..3241813 - 384 WP_000497137.1 biofilm formation regulator BssR -
NML26_RS15855 (3242026) 3242026..3243351 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
NML26_RS15860 (3243577) 3243577..3243963 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML26_RS15865 (3243953) 3243953..3244282 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NML26_RS15870 (3244352) 3244352..3245680 - 1329 WP_000086919.1 GGDEF domain-containing protein -
NML26_RS15875 (3245688) 3245688..3248036 - 2349 Protein_3115 EAL domain-containing protein -
NML26_RS15880 (3248214) 3248214..3249125 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T251521 WP_000539521.1 NZ_CP101210:3243577-3243963 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT251521 WP_001280945.1 NZ_CP101210:3243953-3244282 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References