Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2684175..2684811 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name hicA Uniprot ID A0A5F1EUB3
Locus tag NML26_RS13105 Protein ID WP_000813796.1
Coordinates 2684635..2684811 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NML26_RS13100 Protein ID WP_076838470.1
Coordinates 2684175..2684591 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS13080 (2679327) 2679327..2680268 - 942 WP_001251307.1 ABC transporter permease -
NML26_RS13085 (2680269) 2680269..2681282 - 1014 WP_000220433.1 ABC transporter ATP-binding protein -
NML26_RS13090 (2681300) 2681300..2682445 - 1146 WP_000047448.1 ABC transporter substrate-binding protein -
NML26_RS13095 (2682690) 2682690..2684096 - 1407 WP_254824968.1 PLP-dependent aminotransferase family protein -
NML26_RS13100 (2684175) 2684175..2684591 - 417 WP_076838470.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NML26_RS13105 (2684635) 2684635..2684811 - 177 WP_000813796.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NML26_RS13110 (2685033) 2685033..2685263 + 231 WP_000494243.1 YncJ family protein -
NML26_RS13115 (2685355) 2685355..2687316 - 1962 WP_001317809.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NML26_RS13120 (2687389) 2687389..2687925 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
NML26_RS13125 (2688017) 2688017..2689189 + 1173 WP_001236216.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T251519 WP_000813796.1 NZ_CP101210:c2684811-2684635 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15219.59 Da        Isoelectric Point: 4.5908

>AT251519 WP_076838470.1 NZ_CP101210:c2684591-2684175 [Escherichia coli]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1EUB3

Antitoxin

Source ID Structure

References