Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2598897..2600479 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag NML26_RS12750 Protein ID WP_001125469.1
Coordinates 2599163..2600479 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NML26_RS12745 Protein ID WP_001296726.1
Coordinates 2598897..2599163 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS12730 (2594041) 2594041..2594994 + 954 WP_000154356.1 transcriptional regulator LsrR -
NML26_RS12735 (2595073) 2595073..2596665 + 1593 WP_000113152.1 autoinducer-2 kinase -
NML26_RS12740 (2596815) 2596815..2598704 + 1890 Protein_2495 autotransporter barrel domain-containing lipoprotein -
NML26_RS12745 (2598897) 2598897..2599163 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NML26_RS12750 (2599163) 2599163..2600479 + 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NML26_RS12755 (2600755) 2600755..2601021 + 267 Protein_2498 AraC family transcriptional regulator -
NML26_RS12760 (2601455) 2601455..2602018 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
NML26_RS12765 (2602380) 2602380..2603090 + 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T251518 WP_001125469.1 NZ_CP101210:2599163-2600479 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT251518 WP_001296726.1 NZ_CP101210:2598897-2599163 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References