Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1492267..1492892 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NML26_RS07255 Protein ID WP_000911329.1
Coordinates 1492494..1492892 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NML26_RS07250 Protein ID WP_000450524.1
Coordinates 1492267..1492494 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS07225 (1488067) 1488067..1488537 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NML26_RS07230 (1488537) 1488537..1489109 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NML26_RS07235 (1489255) 1489255..1490133 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NML26_RS07240 (1490150) 1490150..1491184 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NML26_RS07245 (1491397) 1491397..1492110 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NML26_RS07250 (1492267) 1492267..1492494 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NML26_RS07255 (1492494) 1492494..1492892 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NML26_RS07260 (1493039) 1493039..1493902 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NML26_RS07265 (1493917) 1493917..1495932 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
NML26_RS07270 (1496006) 1496006..1496704 + 699 WP_000679819.1 esterase -
NML26_RS07275 (1496785) 1496785..1496985 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T251512 WP_000911329.1 NZ_CP101210:1492494-1492892 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251512 WP_000450524.1 NZ_CP101210:1492267-1492494 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References