Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 353691..354322 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag NML26_RS01655 Protein ID WP_001260301.1
Coordinates 353691..353966 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag NML26_RS01660 Protein ID WP_000593557.1
Coordinates 353963..354322 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS01640 (348695) 348695..349762 + 1068 WP_000361470.1 HlyD family secretion protein -
NML26_RS01645 (349759) 349759..352494 + 2736 WP_000149178.1 ribosome-associated ATPase/putative transporter RbbA -
NML26_RS01650 (352494) 352494..353618 + 1125 WP_001318088.1 ABC transporter permease -
NML26_RS01655 (353691) 353691..353966 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
NML26_RS01660 (353963) 353963..354322 + 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NML26_RS01665 (354442) 354442..354843 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NML26_RS01670 (354849) 354849..355655 - 807 WP_000173650.1 nickel import ATP-binding protein NikE -
NML26_RS01675 (355652) 355652..356416 - 765 WP_001136206.1 nickel import ATP-binding protein NikD -
NML26_RS01680 (356416) 356416..357249 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NML26_RS01685 (357246) 357246..358190 - 945 WP_000947063.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T251507 WP_001260301.1 NZ_CP101210:353691-353966 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT251507 WP_000593557.1 NZ_CP101210:353963-354322 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References