Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4425023..4425618 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag NML27_RS21165 Protein ID WP_019842229.1
Coordinates 4425023..4425373 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NML27_RS21170 Protein ID WP_001223213.1
Coordinates 4425367..4425618 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS21145 (4420353) 4420353..4421375 - 1023 WP_001550507.1 ABC transporter permease -
NML27_RS21150 (4421389) 4421389..4422891 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
NML27_RS21155 (4423023) 4423023..4423979 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NML27_RS21160 (4424289) 4424289..4424819 + 531 WP_000055075.1 inorganic diphosphatase -
NML27_RS21165 (4425023) 4425023..4425373 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
NML27_RS21170 (4425367) 4425367..4425618 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NML27_RS21175 (4425830) 4425830..4426171 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
NML27_RS21180 (4426174) 4426174..4429953 - 3780 WP_001596432.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T251489 WP_019842229.1 NZ_CP101197:c4425373-4425023 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT251489 WP_001223213.1 NZ_CP101197:c4425618-4425367 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References