Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4413361..4413883 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NML27_RS21105 Protein ID WP_001105433.1
Coordinates 4413361..4413651 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NML27_RS21110 Protein ID WP_000212715.1
Coordinates 4413641..4413883 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS21090 (4408529) 4408529..4410184 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
NML27_RS21095 (4410578) 4410578..4412716 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
NML27_RS21100 (4412896) 4412896..4413360 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NML27_RS21105 (4413361) 4413361..4413651 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML27_RS21110 (4413641) 4413641..4413883 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NML27_RS21115 (4414075) 4414075..4414461 - 387 WP_001232246.1 cytochrome b562 -
NML27_RS21120 (4414644) 4414644..4415996 - 1353 WP_001162173.1 metalloprotease PmbA -
NML27_RS21125 (4416090) 4416090..4416641 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NML27_RS21130 (4416791) 4416791..4418164 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T251488 WP_001105433.1 NZ_CP101197:c4413651-4413361 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT251488 WP_000212715.1 NZ_CP101197:c4413883-4413641 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References