Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3737327..3737945 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NML27_RS17985 Protein ID WP_001291435.1
Coordinates 3737727..3737945 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NML27_RS17980 Protein ID WP_000344800.1
Coordinates 3737327..3737701 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS17970 (3732416) 3732416..3733609 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NML27_RS17975 (3733632) 3733632..3736781 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NML27_RS17980 (3737327) 3737327..3737701 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NML27_RS17985 (3737727) 3737727..3737945 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NML27_RS17990 (3738117) 3738117..3738668 + 552 WP_000102564.1 maltose O-acetyltransferase -
NML27_RS17995 (3738784) 3738784..3739254 + 471 WP_000136192.1 YlaC family protein -
NML27_RS18000 (3739418) 3739418..3740968 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NML27_RS18005 (3741010) 3741010..3741363 - 354 WP_001550741.1 DUF1428 family protein -
NML27_RS18015 (3741742) 3741742..3742053 + 312 WP_000409911.1 MGMT family protein -
NML27_RS18020 (3742084) 3742084..3742656 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251485 WP_001291435.1 NZ_CP101197:3737727-3737945 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251485 WP_000344800.1 NZ_CP101197:3737327-3737701 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References