Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3331422..3332127 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NML27_RS16200 Protein ID WP_000539521.1
Coordinates 3331422..3331808 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NML27_RS16205 Protein ID WP_001280945.1
Coordinates 3331798..3332127 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS16180 (3327426) 3327426..3328052 + 627 WP_001295292.1 glutathione S-transferase GstB -
NML27_RS16185 (3328049) 3328049..3329164 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NML27_RS16190 (3329275) 3329275..3329658 - 384 WP_000497137.1 biofilm formation regulator BssR -
NML27_RS16195 (3329871) 3329871..3331196 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NML27_RS16200 (3331422) 3331422..3331808 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML27_RS16205 (3331798) 3331798..3332127 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NML27_RS16210 (3332197) 3332197..3333525 - 1329 WP_001550887.1 GGDEF domain-containing protein -
NML27_RS16215 (3333533) 3333533..3335881 - 2349 WP_001550886.1 EAL domain-containing protein -
NML27_RS16220 (3336059) 3336059..3336970 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T251484 WP_000539521.1 NZ_CP101197:3331422-3331808 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT251484 WP_001280945.1 NZ_CP101197:3331798-3332127 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References