Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2641381..2642019 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NML27_RS12635 Protein ID WP_000813795.1
Coordinates 2641843..2642019 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NML27_RS12630 Protein ID WP_076797675.1
Coordinates 2641381..2641797 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS12610 (2636533) 2636533..2637474 - 942 WP_001251315.1 ABC transporter permease -
NML27_RS12615 (2637475) 2637475..2638488 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NML27_RS12620 (2638506) 2638506..2639651 - 1146 Protein_2472 ABC transporter substrate-binding protein -
NML27_RS12625 (2639896) 2639896..2641302 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NML27_RS12630 (2641381) 2641381..2641797 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NML27_RS12635 (2641843) 2641843..2642019 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NML27_RS12640 (2642241) 2642241..2642471 + 231 WP_023910283.1 YncJ family protein -
NML27_RS12645 (2642563) 2642563..2644524 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NML27_RS12650 (2644597) 2644597..2645133 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NML27_RS12655 (2645225) 2645225..2646397 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T251482 WP_000813795.1 NZ_CP101197:c2642019-2641843 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT251482 WP_076797675.1 NZ_CP101197:c2641797-2641381 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References