Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 977245..977899 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NML27_RS04780 Protein ID WP_000244781.1
Coordinates 977492..977899 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NML27_RS04775 Protein ID WP_000354046.1
Coordinates 977245..977511 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS04755 (973333) 973333..974766 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
NML27_RS04760 (974811) 974811..975122 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NML27_RS04765 (975286) 975286..975945 + 660 WP_000250274.1 hemolysin III family protein -
NML27_RS04770 (976022) 976022..977002 - 981 WP_000886079.1 tRNA-modifying protein YgfZ -
NML27_RS04775 (977245) 977245..977511 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NML27_RS04780 (977492) 977492..977899 + 408 WP_000244781.1 protein YgfX Toxin
NML27_RS04785 (977939) 977939..978460 - 522 WP_001055874.1 flavodoxin FldB -
NML27_RS04790 (978572) 978572..979468 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NML27_RS04795 (979493) 979493..980203 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NML27_RS04800 (980209) 980209..981942 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T251474 WP_000244781.1 NZ_CP101197:977492-977899 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT251474 WP_000354046.1 NZ_CP101197:977245-977511 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References