Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1233074..1233852 Replicon chromosome
Accession NZ_CP101176
Organism Xanthomonas campestris pv. campestris strain CN08

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag XCCCN08v2_RS05185 Protein ID WP_011038220.1
Coordinates 1233074..1233565 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag XCCCN08v2_RS05190 Protein ID WP_011038219.1
Coordinates 1233562..1233852 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XCCCN08v2_RS05170 1229402..1230277 + 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -
XCCCN08v2_RS05175 1230927..1231604 + 678 WP_003490678.1 response regulator transcription factor -
XCCCN08v2_RS05180 1231597..1232931 + 1335 WP_162808569.1 HAMP domain-containing sensor histidine kinase -
XCCCN08v2_RS05185 1233074..1233565 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
XCCCN08v2_RS05190 1233562..1233852 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
XCCCN08v2_RS05195 1233927..1234328 - 402 WP_040940795.1 SymE family type I addiction module toxin -
XCCCN08v2_RS05200 1234471..1235579 + 1109 WP_087942068.1 IS3 family transposase -
XCCCN08v2_RS05205 1236064..1236687 - 624 WP_075285407.1 dephospho-CoA kinase -
XCCCN08v2_RS05210 1236701..1237564 - 864 WP_075285408.1 A24 family peptidase -
XCCCN08v2_RS05215 1237570..1238826 - 1257 WP_075285409.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1224045..1248622 24577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T251464 WP_011038220.1 NZ_CP101176:c1233565-1233074 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT251464 WP_011038219.1 NZ_CP101176:c1233852-1233562 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References