Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2387261..2388221 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name - Uniprot ID A0A7U7FM81
Locus tag YE105_RS10955 Protein ID WP_013649871.1
Coordinates 2387261..2387719 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7U7FM48
Locus tag YE105_RS10960 Protein ID WP_013649872.1
Coordinates 2387775..2388221 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS10925 2383076..2383741 + 666 WP_005161029.1 phage shock protein PspA -
YE105_RS10930 2383903..2384130 + 228 WP_005161022.1 envelope stress response membrane protein PspB -
YE105_RS10935 2384130..2384534 + 405 WP_013649869.1 envelope stress response membrane protein PspC -
YE105_RS10940 2384580..2384819 + 240 WP_005161016.1 phage shock protein PspD -
YE105_RS10945 2384800..2386197 + 1398 WP_005161012.1 YcjX family protein -
YE105_RS10950 2386194..2387258 + 1065 WP_013649870.1 YcjF family protein -
YE105_RS10955 2387261..2387719 - 459 WP_013649871.1 RES family NAD+ phosphorylase Toxin
YE105_RS10960 2387775..2388221 - 447 WP_013649872.1 DUF2384 domain-containing protein Antitoxin
YE105_RS10965 2388541..2390118 + 1578 WP_020283144.1 transcriptional regulator TyrR -
YE105_RS10970 2390365..2390868 - 504 WP_005161000.1 thiol peroxidase -
YE105_RS10975 2391021..2391992 + 972 WP_013649874.1 L-Ala-D/L-Glu epimerase -
YE105_RS10980 2391989..2392696 - 708 WP_005160995.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17158.54 Da        Isoelectric Point: 4.6717

>T25146 WP_013649871.1 NC_015224:c2387719-2387261 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Download         Length: 459 bp

>T25146 NC_015224:c2387719-2387261 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16322.77 Da        Isoelectric Point: 9.8753

>AT25146 WP_013649872.1 NC_015224:c2388221-2387775 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Download         Length: 447 bp

>AT25146 NC_015224:c2388221-2387775 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FM81

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FM48

References